Dennis Hoffman, Ph.D.

Director, Visual Biochemistry Laboratory

Ph.D., University of North Dakota, 1979

Office: 214-363-3911 ext.125



Omega-3 fatty acids, biochemistry, nutrition, infant development, retinitis pigmentosa, neuroprotection, DHA, clinical trials

Representative Publications:

Hoffman DR , Birch EB, Birch DG, Uauy R, Castañeda YS, Lapus MG, Wheaton DH. Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. J Pediatr Gastroenterol Nutr 2000; 31: 540-53.

Hoffman DR , DeMar JC, Heird WC, Birch DG, Anderson RE. Impaired synthesis of docosahexaenoic acid ( DHA) in patients with X-linked retinitis pigmentosa (XLRP). J Lipid Res 2001 ;42 :1395-1401.

Hoffman DR, Theuer RC, Castañeda YS. Wheaton DKH, Morale SE, Wiedemann LE, Birch E E. M aturation of visual acuity is accelerated in breast-fed term infants fed baby food containing DHA-enriched egg yolk. J Nutrition 2004;134: 2307-2313.

Hoffman DR , Locke KG, Wheaton DH, Fish GE, Spencer, R, Birch DG. A randomized, placebo-controlled clinical trial of docosahexaenoic acid supplementation for X-linked retinitis pigmentosa. Amer J Ophthalmol 2004; 137: 704-718.

Hoffman DR, Boettcher JA, Diersen-Schade DA. Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: A review of randomized controlled trials. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2009; 81:151-158.

Hoffman DR, Hughbanks-Wheaton DK, Pearson NS, Fish GE, Spencer R, Takacs A, Klein M, Locke KG, Birch DG. Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): A randomized clinical trial. JAMA Ophthalmol. 2014; 132:866-873.

Hughbanks-Wheaton DK, Birch DG, Fish GE, Spencer R, Pearson NS, Takacs A, Hoffman DR. Safety assessment of docosahexaenoic acid in X-linked retinitis pigmentosa: The 4-year DHAX trial. Invest Ophthalmol Vis Sci. 2014; 55:4958-4966.

Mailing Address:

Dr. Dennis Hoffman

Retina Foundation of the Southwest

9600 N. Central Expressway, Suite 200

Dallas, TX 75231